The CLARITY Research Group at Institut Langevin (ESPCI Paris, CNRS, PSL University), led by Pedro Mecê and Olivier Thouvenin, develops advanced label-free optical imaging technologies to investigate the living human retina and biological tissues at cellular resolution. The group focuses on accessing structural, dynamic, and functional information in vivo by pushing the limits of interferometric and phase-contrast imaging.
At the interface of optical physics and biomedical research, CLARITY designs new imaging architectures aimed at revealing neuronal and vascular activity with high spatial and temporal precision. Current research applies these methods to characterize retinal neurovascular coupling, investigating light-evoked neuronal and vascular responses as potential early biomarkers of Alzheimer’s disease (ERC project MIRACLE-AD). The group also develops label-free approaches to probe cellular dynamics in retinal organoids and other biological tissues.
